Publications - Hsiai LabUCLA - Cardiovascular Engineering Research Laboratory


P. Fei, J. Nie, Y. Ding, J. Lee, S. Li, Z. Yu, H. Zhang, T. Yu, M. Hagiwara, T. Segura, C.-M. Ho, D. Zhu, T. K. Hsiai*, "Sub-voxel light-sheet microscopy for high-resolution, high-throughput volumetric imaging of large biomedical specimens", Advanced Photonics. 1(1), 016002 (2019) (cover page) Click to View

J. Chen, Y. Ding, C.-C. Chang, K. Baek, T. K. Hsiai*, R. R. S. Packard*, "Integrating light-sheet imaging and computation to quantify doxorubicin-induced Notch signaling", J Clin Investigation Insight, 2019. Apr 18;4(8). pii: 125362.

A. Shigeta, V. Huang, J. Zuo, R. Basada, Y. Nakashima, Y. Lu, Y. Ding, M. Pellegrini, R. P. Kulkarni, T. Hsiai, A. Deb, B. Zhou, H. Nakano, A. Nakano, "Endocardially-derived macrophages are essential for valvular remodeling", Developmental Cell. 2019 Mar 11;48(5):617-630.

S. Ranjbarvaziri, S. Park, J. L. Engel, B. V. Handel, P. Zhao, Y. Ding, K. Sung, T. K. Hsiai, D. M. Moore, B. G. Novitch, D. Sahoo, Y.-J. Nam, R. Ardehali*, "Cardiac Microenvironment Supersedes Developmental Origin for Fibroblast-to-Cardiomyocyte Reprogramming", 2019. (In revision)

Hsu, J, Chen, J, Vedula V, Lee J, Baek K, Ding Y, Packard, R, Tintut Y, Demer, LL, Marsden, A, Hsiai, T*. Contractile and Hemodynamic Forces Coordinate Notch1b-Mediated Outflow Tract Valve Formation. J Clin Investigation Insight 2019 Apr 11;5. pii: 124460.

Ma X, Ding Y, Zhang H, Qiu Q, Dvornikov AV, Kim M, Wang Y, Lowerison M, Herrmann J, Ekker S, Hsiai TK, Lin X and Xu X. Retinoid X receptor alpha is a spatiotemporally-specific therapeutic target for doxorubicin-induced cardiomyopathy in adult zebrafish. bioRxiv. 2018. DOI: 10.1101/490706

Yuan Luo, Parinaz Abiri, Rene R.S. Packard, Tzung K. Hsiai, Yu-Chong Tai. DUAL-FUNCTION INTRAVASCULAR CATHETER FOR ATHEROSCLEROSIS DIAGNOSTICS. 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)

Parinaz Abiri , Alireza Yousefi, Arash Abiri, Sandra Duarte-Vogel, Tzu-Chieh Chou, Varun Gudapati , Yichen Ding, Kim-Lien Nguyen, Jeffrey J. Hsu , Ahmad Abiri, Dejan Markovic, Yu-Chong Tai, Tzung K. Hsiai. Intravascularly Deployed Wireless Micro-Scale Pacer. 2019 (in revision)

Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, and Xu X. Identification of dnajb6(L) and mtor as two genetic modifiers for bag3 cardiomyopathy via zebrafish genetics. 2019 (in revision)

Lenning M, Fortunato J, Le T, Clark I, Sherpa A, Yi S, Hofsteen P, Thamilarasu G, Yang J, Xu X, Han HD, Hsiai TK, Cao H. Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection. Sensors (Basel). 2017 Dec 28;18(1). PMCID: PMC5796315

Kyung In Baek, René Packard, Arian saffari, Zhao Ma, Anh Luu, Andrew Pieterson, Amir Kaboodrangi, Hilary Yen, Jeffrey Hsu, Bin Ren, Constantinos Sioutas, Rongsong Li, and Tzung Hsiai*. Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antixoidant & Redox Signaling. 2018 May 1;28130:1209-1223. PMCID: PMC5912723

Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nature Communications. 2018 Feb 21;9(1):754. PMCID: PMC582185

Jeffrey Hsu, Jinxiu Lu, Soban Umar, Jason Lee, Rajan Kulkarni, Yichen Ding, Tzung Hsiai, Akishige Hokugo, Ioannis Gkouveris, Sotirios Tetradis ,Ichiro Nishimura, Linda Demer, Yin Tintut. Effects of bone anabolic therapy on progression of calcific aortic vasculopathy in Apoe-/- mice. Am J Physiology: Heart 2018 Feb 16 [Epub ahead of print]

Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair. Curr Cardiol Rep. 2018 Mar 24;20(5):35. Review. PMCID: PMC5987244

Baek KI, Ding Y, Chang CC, Chang M, Sevag Packard RR, Hsu JJ, Fei P, Hsiai TK. Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging. Prog Biophys Mol Biol. 2018 Oct;138:105-115. Review. PMCID: PMC6226366

Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 Jul 12;3(13). PMCID: PMC6124527

Abiri A, Ding Y, Abiri P, Packard RRS, Vedula V, Marsden A, Kuo CJ, Hsiai TK. Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach. Ann Biomed Eng. 2018 Dec;46(12):2177-2188. PMCID: PMC6249076

Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 Aug 23;3(16). PMCID: PMC6141183

Messerschmidt V, Bailey Z, Baek KI, Bryant R, Li R, Hsiai TK, Lee J. Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart. J Vis Exp. 2018 Aug 10;(138). PMCID: PMC6126686

Ding Y, Bailey Z, Messerschmidt V, Nie J, Bryant R, Rugonyi S, Fei P, Lee J, Hsiai TK. Light-sheet Fluorescence Microscopy for the Study of the Murine Heart. J Vis Exp. 2018 Sep 15;(139). PMCID: PMC6235202

Yichen Ding, Jianguo Ma, Adam D. Langenbacher, Kyung In Baek, Chih-Chiang Chang, Rajan P. Kulkarni, John Belperio, Shi Wei, Sara Ranjbarvazirj Reza Ardehali, Yin Tintut, Linda L. Demer, Jau-Nian Chen, Juhyun Lee, René R. Sevag Packard, Peng Fei, Tzung K. Hsiai*.Frontier Applications of Light-Sheet Imaging for Elucidating Cardiovascular Development and Disease. J Clinical Investigation Insight (In Press)

A. Abiri, Y. Ding, V. Vedula, P. Abiri, R. R. S. Packard, A. Marsden, T. K. Hsiai*, "Deformable Image Registration in 4-Dimensional Cardiac Imaging for Interactive Virtual Reality", Annals of Biomedical Engineering, 2018. (in press)

Y. Ding, Z. Bailey, V. Messerschmidt, R. Bryant, J. Lee*, T. K. Hsiai*, "Light-sheet fluorescence microscopy for the study of the murine heart", Journal of Visualized Experiments, 2018. (In press).

Kyung In Baek, Yichen Ding, Chih-Chiang Chang, Megan Chang, René R. Sevag Packard, Jeffrey J. Hsu, Peng Fei, Tzung K. Hsiai*. Advanced Microscopy to Elucidate Cardiovascular Injury and Regeneration: 4D Light-Sheet Imaging. Progress in Biophysics and Molecular Biology. 2018 May 9. [Epub ahead of print] Review.

Juhyun Lee ,Vijay Vedula ,Junjie Chen, Jeffrey Hsu, Yichen Ding, Kyung In Baek, Chih-Chiang Chang, Hanul Kang, Peng Fei, Cheng-Ming Chuong, Rongsong Li, Rene Packard, Alison Marsden, Tzung Hsiai*. 4-D Hemodynamic Forces Regulate Trabeculation and Consequent Cardiac Function during Development. J Clinical Investigation Insight. 2018 Jul 12;3(13). [Epub ahead of print]

Kyung In Baek, René Packard, Arian saffari, Zhao Ma, Anh Luu, Andrew Pieterson, Amir Kaboodrangi, Hilary Yen, Jeffrey Hsu, Bin Ren, Constantinos Sioutas, Rongsong Li, and Tzung Hsiai*. Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antixoidant & Redox Signaling, 2018 May 1;28(13):1209-1223 (Cover Page).

Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK*. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair. Curr Cardiol Rep. 2018 Mar 24;20(5):35

Yuan Luo, Parinaz Abiri, Shell Zhang, Chih-Chiang Chang, Amir H. Kaboodrangi, René R. Sevag Packard, Rongsong Li, Alex Bui, Rajesh Kumar, Mary Woo, Zhaoping Li, Yu-Chong Tai, Tzung K. Hsiai*. Non-Invasive Electrical Impedance Tomography for Multi-Scale Detection of Liver Fat Content. Theranostics. 2018 Feb 8;8(6):1636-1647. PMCID:PMC5858172

Konstantina-Ioanna Sereti, Ngoc Nguyen, Paniz Kamran, Peng Zhao, Sarah Ranjbarvaziri, Shuin Park, James Engel, Kevin Sung, Rajan Kulkarni, Yichen Ding, Tzung Hsiai, Hanna K. A. Mikkola, Debashis Sahoo, M. Luisa Iruela-Arispe, and Reza Ardehali. Clonal analysis of cardiomyocyte generation during development and injury using the Rainbow model. Nature Communications. 2018 Feb 21;9(1):754.

Kyung baek, Tyler Beebe, Hilary Yen, Amirhossein Kaboodrangi, Nelson Jen, Juhyun Lee, Peng Fei, Peipei Ping, David Liem, Rongsong Li, Tzung K. Hsiai*. Flow-Responsive VEGFR-PKCɛ Signaling Mediates Glycolytic Metabolites for Vascular Repair. Antioxid Redox Signal. 2018 Jan 1;28(1):31-43 (Cover Page).

Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017 Aug 17;7(1):8603. doi: 10.1038/s41598-017-09152-x.

Baek KI, Li R, Jen N, Choi H, Kaboodrangi A, Ping P, Liem D, Beebe T, Hsiai TK.Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair. Antioxid Redox Signal. 2017 Sep 21. doi: 10.1089/ars.2017.7044. [Epub ahead of print]

Packard RRS, Luo Y, Abiri P, Jen N, Aksoy O, Suh WM, Tai YC, Hsiai TK. 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions. Theranostics. 2017 Jun 22;7(9):2431-2442. doi: 10.7150/thno.19184. eCollection 2017.

Abiri P, Abiri A, Packard RRS, Ding Y, Yousefi A, Ma J, Bersohn M, Nguyen KL, Markovic D, Moloudi S, Hsiai TK. Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system. Sci Rep. 2017 Jul 21;7(1):6180. doi: 10.1038/s41598-017-06493-5.

Lee J, Chou TC, Kang D, Kang H, Chen J, Baek KI, Wang W, Ding Y, Carlo DD, Tai YC, Hsiai TK. A Rapid Capillary-Pressure Driven Micro-Channel to Demonstrate Newtonian Fluid Behavior of Zebrafish Blood at High Shear Rates. Sci Rep. 2017 May 16;7(1):1980. doi: 10.1038/s41598-017-02253-7.

Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT.Rigor and Reproducibility in Analysis of Vascular Calcification. Circ Res. 2017 Apr 14;120(8):1240-1242. doi: 10.1161/CIRCRESAHA.116.310326. No abstract available.

Li R, Yang J, Saffari A, Jacobs J, Baek KI, Hough G, Larauche MH, Ma J, Jen N, Moussaoui N, Zhou B, Kang H, Reddy S, Henning SM, Campen MJ, Pisegna J, Li Z, Fogelman AM, Sioutas C, Navab M, Hsiai TK.Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites. Sci Rep. 2017 Feb 17;7:42906. doi: 10.1038/srep42906.

Ding Y, Lee J, Ma J, Sung K, Yokota T, Singh N, Dooraghi M, Abiri P, Wang Y, Kulkarni RP, Nakano A, Nguyen TP, Fei P, Hsiai TK. Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution. Sci Rep. 2017 Feb 6;7:42209. doi: 10.1038/srep42209.

Manuja Sharma, Karinne Barbosa, Victor Ho, Devon Griggs, Tadesse Ghirmai, Sandeep Krishnan, Tzung Hsiai, J.-C. Chiao, Hung Cao. Cuff-less and Continuous Blood Pressure Monitoring: A Methodological Review. Technologies. 2017, 5(2), 21

Yuan Luo, Parinaz Abiri, Shell Zhang, Chih-Chiang Chang, Amir H. Kaboodrangi, René R. Sevag Packard, Rongsong Li, Alex Bui, Rajesh Kumar, Mary Woo, Zhaoping Li, Yu-Chong Tai, Tzung K. Hsiai*. Non-Invasive Electrical Impedance Tomography for Multi-Scale Detection of Liver Fat Content. Theranostics (in revision)

Vijay Vedula, Juhyun Lee, hao Xu,Jay C.-C, Kuo, Tzung K. Hsiai, Alison L. Marsden. A Method to Quantify Mechanobiological Forces during Zebrafish Cardiac Development using4-D Light-Sheet Imaging and Computational Modeling. PLOS Computational Biology (in revision)

Yichen Ding, Arash Abiri, Shuoran Li, Parinaz Abiri, Juhyun Lee, Chih-Chiang Chang, Kyung In Baek, Elias Sideris, Yilei Li , Alexander Bui, Tatiana Segura, Thao P. Nguyen, René R. Sevag Packard, Peng Fei, Tzung K. Hsiai*. Recapitulating 4-D Light-Sheet Imaging for Interactive Virtual Reality to Uncover DevelopmentalCardiac Mechanics and Physiology Journal of Clinical Investigation Insight (in revision).

Kyung In Baek, René Packard, Arian saffari, Zhao Ma, Anh Luu, Andrew Pieterson, Amir Kaboodrangi, Hilary Yen, Jeffrey Hsu, Bin Ren, Constantinos Sioutas, Rongsong Li, and Tzung Hsiai*. FOXO1/Notch Signaling Modulates Ultrafine Particles-Impaired Vascular Regeneration, Antixoidant & Redox Signaling (in revision).

Konstantina-Ioanna Sereti, Ngoc Nguyen, Paniz Kamran, Peng Zhao, Sarah Ranjbarvaziri, Shuin Park, James Engel, Kevin Sung, Rajan Kulkarni, Yichen Ding, Tzung Hsiai, Hanna K. A. Mikkola, Debashis Sahoo, M. Luisa Iruela-Arispe, and Reza Ardehali. Clonal analysis of cardiomyocyte generation during development and injury using the Rainbow model. Nature Communications (in press)

Linda Demer, Yin Tintut, KimoLien Nguyen, Tzung Hsiai,Jason T. Lee. Rigor and reproducibility in analysis of vascular calcification. Circulation Research. Viewpoint. 2016 (accepted).

Elias Sideris, Donald R. Griffin, Yichen Ding, Shuoran Li, Tzung Hsiai, Tatiana Segura. Human fibroblast growth within microporous scaffolds shows preference for smaller pores. ACE Biomaterials Science & Engineering 2016, September 2 (11), pp 2034–2041

Teng Ma, Bill Zhou, Tzung K. Hsiai, K. Kirk Shung. Intravascular Ultrasound (IVUS)-Based Multimodal Intravascular Imaging System: A Synergistic Strategy to Characterize Vulnerable Plaque. Ultrasonic Imaging. 2016 Sep;38(5):314-31.

Tyler Beebe, Hilary Yen, Amirhossein Kaboodrangi, Nelson Jen, Juhyun Lee, Peng Fei, Peipei Ping, Rongsong Li, David Liem, Tzung K. Hsiai*. Shear Stress-Induced Glycolytic Metabolites Promote Vascular Repair, Antioxidants & Redox Signaling (in revision)

Kevin Sung, Yichen Ding, Jianguo Ma, Harrison Chen, Vincent Huang, Michelle Cheng, Cindy F. Yang, Jocelyn T. Kim, Daniel Eguchi, Dino Di Carlo, Tzung K. Hsiai, Atsushi Nakano, Rajan P. Kulkarni. Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping. Scientific Reports. 2016 Aug 8;6:30736.

Jianguo Ma, Yuan Luo, René R. Sevag Packard, Teng Ma, Parinaz Abiri, Qifa Zhou, Y-C Tai, Tzung Hsiai*. Intravascular Ultrasound Imaging Guided Electrochemical Impedance Spectroscopy to Assess Metabolically Active Plaque. Sensors & Actuators B-Chemical. (2016) pp. 154-161 (published online May 26, 2016) NIHMS ID: NIHMS 790494

Juhyun Lee, Peng Fei, Nelson Jen, Tyler Beebe, Debra Yelon, Neil Chi, C. C. Cuo, Chih-Ming Ho, Rongsong Li, Tzung Hsiai*. 4-D Light-Sheets to Elucidate Shear Stress Modulation of Cardiac Trabeculation. Journal of Clinical Investigation . 2016 May 2:126(5):1679-90

Juhyun Lee, Peng Fei, René R. Sevag Packard, Konstantina Sereti, Harrison Chen, Hao Xu, XiaoleiXu, Rajan Kulkarni, Reza Ardehali, Jianguo Ma, Chih-Ming Ho, Tzung K. Hsiai*. Cardiac Light-Sheet Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Nature Scientific Reports. 2016 Mar 3;6:22489.

René R. Sevag Packard, MD; XiaoXiao Zhang; Yuan Luo, PhD; Teng Ma, PhD; Nelson Jen; Jianguo Ma; Linda L. Demer; Qifa Zhou; Rongsong Li; Yu-Chong Tai; Tzung K. Hsiai*. Two-point stretchable electrode array for endoluminal electrochemical impedance spectroscopy measurements of lipid-laden atherosclerotic plaques. Annals of Biomedical Engineering. 2016 Feb 8. [Epub ahead of print]

Yang Yang, Zeyu Chen, Xuan Song, Benpeng Zhu, Tzung Hsiai, Pin-I Wu, Rui Xiong, Jing Shi, Yong Chem, Qifa Zhou, K . Kirk Shung. Three dimensional printing of high dielectric capacitor using projection based stereolithography method. Nano Energy. 22:414-421 · March 2016 Read More

Zeyi Guan, Juhyun Lee, Siyan Dong, Nelson Jen, Tyler Beebe, Tzung Hsiai, Chih-Ming Ho and Peng Fei. A Compact Plane Illumination Plugin Device to Enable Light Sheet Fluorescence Imaging on an Inverted Wide-field Microscope. Biomedical Optics Express. 2015 Dec 21;7(1):194-208

C. L. Fei, J. G. Ma, C. T. Chiu, J. A. Williams, W. M. Fong, Z. Y. Chen, R. Xiong, J. Shi, Tzung K. Hsiai, and K. K. Shung, and Q. F. Zhou, Design of matching layers for high-frequency ultrasonic transducers. Applied Physics Letter. 2015 September 21; 107(12): 123505. Published online 2015 September 24.

Teng Ma, Bill Zhou, Tzung K. Hsiai, K. Kirk Shung. Intravascular Ultrasound (IVUS)-Based Multimodal Intravascular Imaging System: A Synergistic Strategy to Characterize Vulnerable Plaque. Ultrasonic Imaging. 2015 Sep 22. pii: 0161734615604829. [Epub ahead of print]

Lee J, Packard, RG, Hsiai, TK*. Blood Flow Modulation of Vascular Dynamics. Current Opinion in Lipidology. 2015 Oct;26(5):376-83.

Rongsong Li, Nelson Jen, Lan Wu, Juhyun Lee, Karen Fang, Katherine Quigley, Katherine Lee, Sky Wang, Bill Zhou, Laurent Vergnes, Yun-Ru Chen, Zhaoping Li, Karen Reue, David Ann, Tzung Hsiai*.Disturbed Flow Induces Autophagy But Impairs Autophagic Flux to Influence Mitochondrial Homeostasis. Antioxidants & Redox Signaling. 2015 Nov 20;23(15):1207-19 (Covered page)

Cao H, Kang B, Lee CA, Shung KK. Hsiai T*. Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration. IEEE Review in Biomedical Engineering. 2015;8:114-24.

Hongbo Yang, Longhou Fang, Rui Zhan, Jeffrey M. Hegarty, Tzung K. Hsiai, Joseph G. Gleeson, Yury I. Miller, and Neil C. Chi. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Developmental Biology. 2015 Aug 15;404(2):49-60.

Shell Zhang, Tyler Beebe, Y. C. Tai, Tzung Hsiai*. Flexible and Waterproof Micro-Sensors to Uncover Zebrafish Circadian Rhythms: The Next Generation of Cardiac Monitoring for Drug Screening. Biosensors and Bioelectronics. 2015 Sep 15;71:150-7.

Yu Zhao, Hung Cao, Tyler Beebe, Hemin Zha, Honglong Chang , Juhyun Lee, Ellen C. Lien, Yu-chong Tai and Tzung K. Hsiai*. Dry-Contact Microelectrode Membranes for Wireless Detection of Electrical Phenotypes in Neonatal Mouse Hearts. Biomedical Microdevices. 2015; 15(2).

Rongsong Li, Kaveh Navab, Greg Hough, Payam Pakbin, Eytan Wine, Jesus Araujo, Alan Fogelman, Constantinos Sioutas, Mohamed Navab, Tzung Hsiai*. Effects of Exposure to Atmospheric Ultrafine Particles on Production of Free Fatty Acids and Lipid Metabolites in the Mouse Small Intestine. Environmental Health Perspectives. 2015 Jan;123(1):34-41

Juhyun, Lee, Hung Cao, Bong Kang, Nelson Jen, Kirk K. Shung, Tzung Hsiai*, Hemodynamics and Ventricular Function In a Zebrafish Model of Injury and Repair. Zebrafish. 2014; 11(5):447-454.

Rongsong Li, Tyler Beebe, Fei Yu, Wakako Takabe, Michael Harrison, Hung Cao, Juhyun Lee, Hongbo Yang, Peidong Han, Kevin Wang, Hirohito Shimizu, Jaunian Chen, Ching-Ling Lien, Neil C. Chi, Tzung K. Hsiai*. Shear Stress-Activated Wnt-Angiopoeitin-2 Signaling Recapitulates Vascular Development and Repair in Zebrafish Embryos. Arteriosclerosis Thrombosis, and Vascular Biology. 2014;34:2268-2275.

Hung Cao, Fei Yu, Yu Zhao, Joy Tai, Juhyun Lee, Ali Darehzereshki, Ellen C. Lien, Neil C. Chi, Yu-Chong Tai, Tzung K. Hsiai*. Wearable multi-channel microelectrode membranes to elucidate electrophysiological phenotypes of injured myocardium. Integrative Biology. 2014 Jul 21;6(8):789-95.

Hsiai T*, Li S, Bursac N. Introduction to the Special Issue on Tissue Engineering and Regenerative Medicine. Ann Biomed Eng. 2014 Jul;42(7):1355-6.

Michael Dickover, Jeffrey M. Hegarty, Kim Ly, Diana Lopez, Hongbo Yang, Ruilin Zhang, Neil Tedeschi, Tzung K. Hsiai, and Neil C. Chi. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Developmental Biology. 2014 May 15;389(2):182-91.

Cao H, Fei Yu, Yu Zhao, Scianmarello N, Lee J, Dai W, Jen N, Beebe T, Li R, Ebrahimi R, Chang DS, Mody FV, John Pacella, Yuchong Tai, Tzung Hsiai*. Stretchable Electrochemical Impedance Sensors for Intravascular Detection of Lipid-Rich Lesions in New Zealand White Rabbits. Biosensors and Bioelectronics. 2014 Apr 15;54:610-6.

Juhyun Lee, Mahdi Esmaily-Moghadam, Ethan Kung, Hung Cao, Tyler Beebe, Longhou Fang, Yuri Miller, Ching-Ling Lien, Neil C. Chi, Alison L. Marsden, and Tzung K. Hsiai*. Moving Domain Computational Fluid Dynamics to Interface with An Embryonic Zebrafish Model of Cardiac Morphogenesis. PLoS ONE. 2013 Aug 23;8(8):e72924.

Yu Zhao, Fei Yu, Hung Cao, Honglong Chang, Xiaoxiao Zhang, Tzung K. Hsiai*, Yu-chong Tai. A Wearable Percutaneous Implant for Long-Term Zebrafish Epicardial ECG Recording. Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013

Yunfeng Du, Melody Shen, James Hill, Payam Pakbin, Constantinos Sioutas, Tzung Hsiai*, Rongsong Li. Ambient ultrafine particle reduces vascular endothelial nitric oxide production via S-glutathionylation of eNOS. Biochemical and Biophysical Research Communication. 2013 Jul 5;436(3):462-6.

Nelson Jen, Fei Yu, Steve Wusmund, Mohamed Hamden, Tzung Hsiai*. Atrial Fibrillation Pacing Decreases Intravascular Shear Stress in a New Zealand White Rabbit Model: Implications in Endothelial Function. Biomechanics and Modeling in Mechanobiology. 2013 Jun;12(4):735-745.

Rongsong Li, Mohamad Navab, Zhi Ning, Payam Pakbin, Greg Hough, Kaveh Navab, Fei Yu, Nelson, Todd Morgan, Caleb Finch, Alan Fogelman, Constantinos Sioutas, Tzung Hsiai*. Ambient Ultrafine Particles Alter Lipid Metabolism and HDL Anti-Oxidant Capacity in LDLR-null Mice. Journal of Lipid Research. 2013 Jun;54(6):1608-15.

Fei Yu, Juhyun Lee, Nelson Jen, Xiang Li, Qiang Zhang, Rui Tang, Qifa Zhou, E.S. Kim, Tzung Hsiai*, Elevated Electrochemical Impedance in the Endoluminal Regions with High Shear Stress: Implication for Assessing Lipid-Rich Atherosclerotic Lesions. Biosensors and Bioelectronics. 2013 May 15;43:237-44.

Rongsong Li, David Mittlestein, Zhi Ning, Tintut Yin, Constantiono Sioutas, Mohamad Navab, Tzung Hsiai*. Atmospheric Ultrafine Particles Promote Vascular Calcification via the NF-κB Signaling Pathway. Am J Physiology-Cell Physiology. 2013 Feb 15;304(4):C362-9.

Rongson Li, David Mittlestein, Karen Fang, Tyler Beebe, Katherine Qingley, Judith Beliner, Tzung Hsiai*. Angiopoeitin-2 Modulates Survivin Expression in OxLDL-Induced Endothelial Cell Apoptosis. Biochemical and Biophysical Research Communication. 2012 Jan 6;417(1):619-22.PMID: 22182412

Fei Yu, Yu Zhao, Xiaohu Dai, Gu Jie, Neil C. Chi, Yuchong Tai, Tzung K. Hsiai*. Flexible Microelectrode Arrays to Interface Epicardial Electrical Signals with Intracardial Calcium Transients in Zebrafish Hearts. Biomedical Microdevices. 2012 Apr;14(2):357-66.

Rongsong Li, David Mittlestein, Rohit Majumdar, Karen Fung, Yin Tintu, Linda Demer, Tzung Hsiai*. A Dynamic Pulsatile Flow Model to Study Calcific Atherosclerotic Plaque Destabilization via OxLDL and Monocytes-Induced Matrix Metalloproteinase. Am J Physiology: Cell Physiol. 2012 Feb;302(4):C658-65. PMID: 22031601

Fei Yu, Xiaohu Dai, Tyler Beebe, Tzung Hsiai*, Electrochemical Impedance Spectroscopy to Characterize Inflammatory Atherosclerotic Plaques. Biosensors and Bioelectronics. 2011 Dec 15;30(1):165-73. PMID:21959227

Takabe W, Jen N, Ai L, Hamilton R, Khalsa B, Darbandi F, Bressler S, Barr M, Li R, Hsiai* TK. Oscillatory Shear Stress Induces Mitochondrial Superoxide Production: Implication of NADPH Oxidase and c-Jun NH2-terminal Kinase Signaling. Antioxidants & Redox Signaling. 2011 Sep 1;15(5):1379-88 PMID: 20919940

Li R, Jen N, Hsiai TK, Assessing mitochondrial redox status by flow cytometric methods: vascular response to fluid shear stress. Curr Protoc Cytom. 2011 Oct;Chapter 9

Yu F, Ai, L., Dai, W. Rozengurt N., Yu, H., Hsiai*, TK. MEMS Thermal Sensors to Detect Changes in Heat Transfer in the Pre-Atherosclerotic Regions of Fat-Fed New Zealand White Rabbits. Ann of Biomed Eng. 2011 Jun;39(6):1736-44. PMID:21380571

Yu F, Edington C, Cheng, N, Yu, H, Kim, ES, Hsiai*, TK. Electrochemical Impedance Spectroscopy to Study Vascular Oxidative Stress. Ann Biomed Eng. 2011 Jan;39(1):287-96. PMID:20652746

Ai L, Zhang L, Dai W, Shung KK, Hsiai*, TK.. Real-time Assessment of Flow Reversal in an Eccentric Arterial Stenotic Model. J Biomechanics 2010 Oct 19;43(14):2678-83.

Yu F, Huang J, Alderz K, Chen JN, Hsiai* T. Evolving Cardiac Conduction Phenotypes in Developing Zebrafish Larvae. Zebrafish. 2010 Dec;7(4):325-31.

Li R, Ning Z, Cui J, Sioutas C, Hsiai TK*, Ultra fine particles emitted from diesel engine modulate vascular endothelial cell permeability: Implication of ZO-1 Expression. Toxicology Letters. 2010 Sep 1;197(3):163-8.

Li R, Ning A, Majundar R, Jen N, Takabe, W, Sioutas C, Hsiai*, TK, Chemical compositions in ultrafine particles emitted from diesel engines induce vascular inflammatory responses via NF-B signaling. Particles & Fiber Toxicology. 2010 Mar 22;7(1):6.

Syed O. Masood, Stephen L. Wasmund, Nazem W. Akoum, Marlene J. Egger, Tzung Hsiai, and Mohamed H. Hamdan. The Effects of Rate and Rhythm Control on Blood Pressure and Antihypertensive Drug Usage in Patients with Atrial Fibrillation and Hypertension Enrolled in the AFFIRM Trial. Journal of Cardiovascular Electrophysiology. 2010 Apr 29.

Yu F, Li R, Parks E, Takabe W, Hsiai* TK, Electrocardiogram Signals to Assess Zebrafish Heart Regeneration: Implication of Long QT Intervals. Ann Biomed Eng. 2010 Jul;38(7):2346-57

Takabe, W., Li, R., Yu F, Li A, Berliner, J., Hsiai* TK. Oxidized LDL-Activated JNK Regulates Mn-SOD Ubiquitination: Implication for Mitochondrial Redox Status and Apoptosis. Arteriosclerosis Thrombosis, and Vascular Biology. 2010;30:436-441.

Ai L, Hsiai* TK. Spatial mapping of real-time quantitative shear stress with vascular oxidative stress. Conf Proc IEEE Eng Med Biol Soc. 2009;1:6557-9. Proceeding.

Li, R, Rouhanizadeh, L. Ai, W. Takabe, T. K. Hsiai*, Shear Stress Regulates Mitochondrial Membrane Potential: Implication of MnSOD. Biochem Biophys Res Commun. 2009 Oct 16;388(2):406-12.

Ai, L., H. Yu, S. Hale, W. Dai, R. A. Kloner, T. K. Hsiai*, Real-time intravascular shear stress in rabbit aorta. IEEE Transactions on Biomedical Engineering. 2009 Jun;56(6):1755-64.

Ai, L. Yu, H., Paraboschi, A., Li, R., T. K. Hsiai*, Optimization of Intravascular Shear Stress Assessment. J of Biomechanics. 2009 Jun;56 (6):1755-64.

J. Zhu, X. Qiu, J. Oiler, C. Yu, T.K. Hsiai, E. S. Kim, and H. Yu, Localized cell lysis using self focused acoustic transducers. BioSensors and BioMicrosystems. Transducer 2009. Proceeding.

Sun, P., Zhou, Y. Yu, F., Parks, E., Lyman, A., Hu, C. H., Zhou, Q., Lien, C. L., T. K. Hsiai*. Micro-ECG to Study Zebrafish Heart Regeneration. Ann of Biomedical Eng 2009 May;37(5):890-901.

Li, R. Ai, L., Khalsa, B., Cui, J., Ning, M., Sioutas, C., J. T. K. Hsiai*. Ultra-Fine Particulates Induce Vascular Oxidative via JNK Activation. Free Radic Biol Med. 2009 Mar 15;46(6):775-82.

Hsiai, T. K*., and Wu, J. Hemodynamic forces regulate embryonic stem cells commitment to vascular progenitors. Current Cardiology Reviews. 2008 November; 3(4): 269-274(6). Review.

H. Yu, L. Ai, M. Rouhanizadeh, D. Patel, E. S. Kim, T. K. Hsiai*. Flexible Polymer Sensors for In Vivo Intravascular Shear Stress Analysis, IEEE/ASME Journal of Micro Electro Mechanical Systems. 2008 October, Volume 17(5). 1178-1186.

R. T. Hamilton, L. Asatryan, J. T. Nilsen, T. K. Hsiai*. LDL protein nitration: Implication for LDL Protein Unfolding. Archives of Biochemistry and Biophysics. 2008 Nov 1;479(1):1-14.

M. Rouhanizadeh, W. Takabe, L. Ai, T. K. Hsiai*, Monitoring oxidative stress in vascular endothelial cells in response to fluid shear stress: from biochemical analyses to micro- and nanotechnologies.Methods Enzymol. 2008;441:111-50. Review.

Ai, L., Rouhanizadeh, M., Wu, J., Yi Chu Y., Miller, J., Heistad, D., Hsiai*, T., Oscillatory Shear Stress Influences Spatial Variations in Vascular MnSOD Expression and Nitrotyrosine Formation, Am J of Physiol: Cell Physiol. 2008 Jun;294(6):C1576-85.

Tzung K. Hsiai*, Mechano-signal Transduction in Vascular Endothelial and Smooth Muscle Cells: The Role of Hemodynamic Forces, Am J of Physiol Cell Physiol, 2008 Mar;294(3):C659-61. Editorial.

Ai, L., Yu, H., Rouhanizadeh, M., Takabe, W., Meng, E., Kim, E.S., Hsiai, T.K*. Polymer-Based Sensors for Dynamic Intravascular Shear Stress Analysis. IEEE ASME Frontiers in Biomedical Devices, Irvine, California, USA, June 18-20, 2008. Proceeding.

H. Yu, L. Ai, M. Rouhanizadeh, R. A. Kloner, E. S. Kim. T. K. Hsiai*, Flexible Shear Stress Sensors for Intravascular Testing, Solid-State Sensors, Actuators Workshop. Hilton Head, SC. 2008 June:142-145. Proceeding.

Tzung K. Hsiai* and Judith Berliner, Oxidative stress as regulators of atherosclerosis in murine models in Current Drug Targets. 2007 Dec;8(12):1222-9. Review.

Cheng, G. Y., Cao, F., Krishnan, M., Huang, M., Li, Z., Xie, X., Sheikh, A., Hoyt, G., Robbins, R., Hsiai, T., Schneider, M., Wu, J., Positron Emission Tomography of Conditional Gene Activation in the Heart, Journal of Molecular and Cellular Cardiology, 2007 Jul;43(1):18-26.

Hsiai*, T., Lin, C., Rouhanizadeh, M, S., Cadenas, E., Hwang, J., Hazen, S. L., Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Bio Med. 2007 Feb 15;42(4):519-29.

Yu, H., Ai, L., Rouhanizadeh, M., Hamilton, R., Hwang, J., Meng, E., Kim, E. S., and Hsiai*, T. K., Polymer-Based Cardiovascular Shear Stress Sensors, IEEE ASME Frontiers in Biomedical Devices. June 7-8, 2007.Proceeding.

Lin, C. T., Tintut, Y., Mack, W., Demer, L. L., Hsiai*, T. K., Mechanical response of a calcified plaque model to fluid shear stress, Annals of Biomedical Engineering, 2006 Oct;34(10):1535-41.

Hwang J, Rouhanizadeh, Eiserich, J., Hodis, H., Hsiai*, T., 17-Estradiol Reverses Oscillatory Flow-Mediated LDL Oxidation, Free Radic Bio Med. 2006 Aug 15;41(4):568-78.

Rouhanizadeh, M., Tang. T., Li, C., Soundararajan, G., Zhou, C. Hsiai*, T., Differentiating oxidized LDL by Nanosensors, Sensors & Actuators: B. Chemical, April, 2006, H114 (2H): 788-798.

Juliana Hwang, Howard N. Hodis, T. K. Hsiai, Liana Asatryan and Alex Sevanian, Role of Annexin II in Estrogen-Induced Macrophage Matrix Metalloproteinase-9, Atherosclerosis, 2006 Nov;189(1):76-82.

Rouhanizadeh, M., Soundararajan, G., Ascara, D., Lo, R., Browand, F., Hsiai*, T., MEMS sensors to resolve spatial variations in shear stress in a 3-D bifurcation model, IEEE Sensors, February, 2006, 6(1):78-88.

DeMaio, L, M. Rouhanizadeh, S. Reddy, Hwang, J., T. Hsiai*. Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H674-83.

Hwang, J., Ing, M., Salemi, S., DeMaio, L., Marcu, L., Sevanian, A., Hsiai*, T., Induction of NADPH Oxidase Subunit, Nox4, by Ox-PAPC: Implications of Superoxide Production, Free Radic Bio Med. 2006 Aug 15;41(4):568-78.

Rouhanizadeh, M., Lin, C. L., Ascara, D., Hsiai*, T. Spatial variations in shear stress at low Reynolds number in a 3-D model, Annals of Biomedical Engineering, Vol. 33, No. 10, October 2005, pp. 1425-1440.

Tang T, Liu X, Li C, Lei B, Zhang D, Rouhanizadeh M, Hsiai* T, Zhou C. Complementary response of In2O3 nanowires and carbon nanotubes to low-density lipoprotein chemical gating. Applied Physics Letter, 86, 03903, 2005.

Soundararajan, G., Rouhinizadeh, M., Yu, H. Kim, E. S., Hsiai*, T., MEMS shear stress sensors for microcirculation, Sensors and Actuators: A. Physical. 2005,118(1):25-32.

Rouhanizadeh M., Tang, T., Li, C., Soundararajan, G., Zhou, C., Hsiai*, T. Applying Indium Oxide Nanowire as Sensitive and Selective Redox Protein Sensors, Proceedings, IEEE Micro Electro Mechanical Systems MEMS. 2004, Vol. 1, 431-435.

11. Hsiai*, T. Salazar, A., Cho, S. K., Wang, P. K., Navab, M., Micro Sensors: Linking Inflammatory Responses with Oscillatory Shear Stress. Annals of Biomedical Engineering, 2004, 32(2):189-201.

Li, C. , Lei, B., Tang, T. , Zhang, D., Rouhanizadeh, M., Hsiai, T. and Zhou, C. Chemical Gating of In2O3 Nanowires by Organic and Bio molecules, Applied Physics Letter , 2003, Vol. 83(19), 2003: 014-6.

Hwang, J., Ing, M., Salazar, A., Navab, M. Sevanian, A., Hsiai*, T. Pulsatile vs. oscillatory flow regulates NADPH Oxidase Subunit: Implication for Native LDL Oxidation. Circulation Research, 2003; 93:1225-1232.

Hsiai*, T. Ing, M., Cho S. K., Wong, P., Hama S., Navab M, Demer, L., Ho, C., Monocyte recruitment to endothelial cells In response to oscillatory shear stress. The FASEB Journal, 2003, Vol. 17:1648-1657.

Hsiai*, T. K., Ing, M., Hwang, J., Salazar, A., Cho, S. K., Wang, P., Ho, C. M., Endothelial Cells: The Living Sensors and Actuators, International Journal of Nonlinear Sciences and Numerical Simulation, 3:169-172, 2002.

Hsiai* T, Cho S. K, Honda, H., Hama S, Navab M, Demer L., Ho C. M. Endothelial cell dynamics under pulsating flow: Significance of high- vs. low shear stress slew rates. Annals of Biomedical Engineering, 2002,30(5):646-656.

Hsiai* T, Yang J. M., Cho S. K. Cho, Yang X., Tai Y. C., Ho C. M., Micromachined particle filters for low power consumption. Journal of Fluids Engineering, ASM, 2002, Vol. 124(4): 1053-1056.

Hsiai* T, Cho S. K., Reddy S, Hama S., Navab M., Demer L., Honda H, Ho, C. M. Pulsatile flow patterns regulate monocyte adhesion to endothelial cells in response to oxidized lipids. Arterioscler Thromb Vasc Biol . 2001, 21(11): 1770-1776.

Honda, H. M., Hsiai, T., Wortham, C. M., Chen, M., Lin, H., Navab, M., Demer. L. L. A Complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells. Atherosclerosis. 2001,158:385-390.

Detrano R, Hsiai T, Wang S, Puentes G, Fallavollita J, Stanford W, Wolfiel C, Georgiou D, Budoff M, Reed J. Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography. Journal of the American College of Cardiology, 1996 Feb, 27(2): 285-90.

Yaghoubi S, Tang W, Wang S, Reed J, Hsiai T, Detrano R, Brundage B. Off line assessment of atherosclerotic coronary calcium from electron beam tomograms. American Journal of Cardiac Imaging, 1995 Oct, 9(4): 231-6.


  • 2016 Virtual Reality Platform for Medical Imaging (IP disclosure: UCLA Case No. 2016-881)
  • 2016 Ultrasonic Transducer Guided Electrochemical Impedance Spectroscopy. Provisional UC-2016-589-1 (U.S. Patent Application No. 62/333,608 filed May, 2016)
  • 2015 Capillary Pressure-Driven Viscometer for the Measurement of Whole Blood Viscosity (California Institute of Technology File No.: CIT-7361-P)
  • 2015 Multi-stage wireless powering mechanism for long-term implantable medical devices (UCLA:2015-214)
  • 2015 The next generation of 4-dimensional optical technique to uncover cardiac developmental dynamics (UCLA: 2015-214)
  • 2015 Flexible balloon-inflatable electrochemical impedance spectroscopy to assess endoluminal pipirich lesions (UCLA Invention disclosure: 2015-182)
  • 2015 4-D light-sheet microscopy to study cardiac developmental dynamics (UCLA Invention disclosure case no. 2015-520)
  • 2014 Wireless and cabled device to monitor ECG with anesthesia (Caltech disclosure: CIT 6971-P) (UCLA: 2015-490)
  • 2014 ECG-gated PW Doppler Ultrasound Device for zebrafish (UC case 2015-087)
  • 2014 3-D Quasi-concentric impedance sensors with inflatable balloon to assess ox-LDL laden lesion (Caltech invention disclosure: CIT File No.: CIT-7021-P)
  • 2012 Polymer-based cardiovascular sensors (United States Patent Number: US8216434)
  • 2011 Concentric Bipolar Electrochemical Impedance Spectroscopy to Assess Vascular Oxidative Stress (US Application Serial No. 13/232,828)
  • 2011 Micro-pipette electrodes to monitor embryonic and larval zebrafish (US Provisional Application No. 61/531,982)
  • 2008 2008 MEMS vascular sensors: Backside wire-bonding for micro circuitry.
    Patent Number: US7367237. Title: MEMS vascular sensor. Issue Date: 05/06/08

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